IMMUNOHISTOCHEMICAL COMPARISON OF P53 EXPRESSION IN ODONTOGENIC KERATOCYSTS, ORTHOKERATINIZING ODONTOGENIC CYSTS AND DENTIGEROUS CYSTS
The odontogenic keratocyst, orthokeratinizing odontogenic cyst, and dentigerous cyst are of odontogenic epithelial origin and demonstrate contrasting clinical behavior which cannot be explained by histologic presentation alone. In stark contrast to the indolent nature of the orthokeratinizing odontogenic cyst and the dentigerous cyst, the odontogenic keratocyst is a destructive cyst with an extraordinary recurrence rate often requiring multiple surgeries to completely eradicate. Recent studies indicate that a mutation of the p53 tumor suppressor gene, the most frequently detected gene mutation in human cancer, may provide the impetus for this aggressive behavior. Mutation of the p53 tumor suppressor gene results in an overexpression of p53 which is detectable through immunohistochemical analysis. Formalin-fixed, paraffin-embedded tissue sections of 26 odontogenic keratocysts, 15 orthokeratinizing odontogenic cysts, and 22 dentigerous cysts were immunohistochemically evaluated for overexpression of p53. The presence of mutated p53, while not uniformly present, was detected in each of the cyst groups. This expression was not statistically different between the groups. Expression of p53 in benign odontogenic cysts does not appear to have prognostic value for predicting aggressive behavior.